Mutagenic Analysis of Hazara Nairovirus Nontranslated Regions during Single- and Multistep Growth Identifies both Attenuating and Functionally Critical Sequences for Virus Replication

Hazara nairovirus (HAZV) is a member of the family Nairoviridae in the order Bunyavirales and closely related to Crimean-Congo hemorrhagic fever virus, which is responsible for severe and fatal human disease. The HAZV genome comprises three segments of negative-sense RNA, named S, M, and L, with non...

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Bibliographic Details
Published in:J Virol
Main Authors: Mega, Daniele F., Fuller, Jack, Álvarez-Rodríguez, Beatriz, Mankouri, Jamel, Hewson, Roger, Barr, John N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431806/
https://ncbi.nlm.nih.gov/pubmed/32522854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00357-20
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