P108 and T109 on E2 Glycoprotein Domain I Are Critical for the Adaptation of Classical Swine Fever Virus to Rabbits but Not for Virulence in Pigs

The classical swine fever virus (CSFV) live attenuated vaccine C-strain is adaptive to rabbits and attenuated in pigs, in contrast with the highly virulent CSFV Shimen strain. Previously, we demonstrated that P108 and T109 on the E2 glycoprotein (E2(P108-T109)) in domain I (E2(DomainI)) rather than...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Xie, Libao, Han, Yuying, Ma, Yuteng, Yuan, Mengqi, Li, Weike, Li, Lian-Feng, Li, Miao, Sun, Yuan, Luo, Yuzi, Li, Su, Hu, Shouping, Li, Yongfeng, Qiu, Hua-Ji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431803/
https://ncbi.nlm.nih.gov/pubmed/32581110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01104-20
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