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CACNA1S haploinsufficiency confers resistance to New World arenavirus infection

Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoo...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sarute, Nicolás, Ross, Susan R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431027/
https://ncbi.nlm.nih.gov/pubmed/32719120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920551117
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