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Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability
Blood platelets are formed by fragmentation of long membrane extensions from bone marrow megakaryocytes in the blood flow. Using lattice-Boltzmann/immersed boundary simulations we propose a biological Rayleigh–Plateau instability as the biophysical mechanism behind this fragmentation process. This i...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7431004/ https://ncbi.nlm.nih.gov/pubmed/32719144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002985117 |
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