Game theoretic centrality: a novel approach to prioritize disease candidate genes by combining biological networks with the Shapley value

BACKGROUND: Complex human health conditions with etiological heterogeneity like Autism Spectrum Disorder (ASD) often pose a challenge for traditional genome-wide association study approaches in defining a clear genotype to phenotype model. Coalitional game theory (CGT) is an exciting method that can...

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Publicat a:BMC Bioinformatics
Autors principals: Sun, Min Woo, Moretti, Stefano, Paskov, Kelley M., Stockham, Nate T., Varma, Maya, Chrisman, Brianna S., Washington, Peter Y., Jung, Jae-Yoon, Wall, Dennis P.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430867/
https://ncbi.nlm.nih.gov/pubmed/32787845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-03693-1
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