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Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation
Tob2, an anti-proliferative protein, promotes deadenylation through recruiting Caf1 deadenylase to the mRNA poly(A) tail by simultaneously interacting with both Caf1 and poly(A)-binding protein (PABP). Previously, we found that changes in Tob2 phosphorylation can alter its PABP-binding ability and d...
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| Udgivet i: | RNA |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7430666/ https://ncbi.nlm.nih.gov/pubmed/32404348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073528.119 |
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