Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

Quorum-sensing (QS) mediated dynamic regulation has emerged as an effective strategy for optimizing product titers in microbes. However, these QS-based circuits are often created on heterologous systems and require careful tuning via a tedious testing/optimization process. This hampers their applica...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Tian, Jinzhong, Yang, Gaohua, Gu, Yang, Sun, Xinqiang, Lu, Yinhua, Jiang, Weihong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Synthetic Biology and Bioengineering
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430639/
https://ncbi.nlm.nih.gov/pubmed/32672817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa602
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