Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells

Abnormal lipid/lipoprotein metabolism induced by obesity may affect spermatogenesis by inhibiting testosterone synthesis in Leydig cells. It is crucial to determine which components of lipoproteins inhibit testosterone synthesis. Circulating oxidized low-density lipoprotein (oxLDL), the oxidized for...

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Publié dans:Cell Death Dis
Auteurs principaux: Jing, Jun, Ding, Ning, Wang, Dandan, Ge, Xie, Ma, Jinzhao, Ma, Rujun, Huang, Xuan, Jueraitetibaike, Kadiliya, Liang, Kuan, Wang, Shuxian, Cao, Siyuan, Zhao, Allan Zijian, Yao, Bing
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429867/
https://ncbi.nlm.nih.gov/pubmed/32796811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02751-z
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