A novel rabbit derived anti-HER2 antibody with pronounced therapeutic effectiveness on HER2-positive breast cancer cells in vitro and in humanized tumor mice (HTM)

BACKGROUND: Antibody based cancer therapies have achieved convincing success rates combining enhanced tumor specificity and reduced side effects in patients. Trastuzumab that targets the human epidermal growth factor related receptor 2 (HER2) is one of the greatest success stories in this field. For...

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Publicat a:J Transl Med
Autors principals: Wege, Anja Kathrin, Kirchhammer, Nicole, Kazandjian, Linda Veronique, Prassl, Sandra, Brandt, Michael, Piendl, Gerhard, Ortmann, Olaf, Fischer, Stephan, Brockhoff, Gero
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429704/
https://ncbi.nlm.nih.gov/pubmed/32799890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02484-9
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