Silencing of spontaneous activity at α4β1/3δ GABA(A) receptors in hippocampal granule cells reveals different ligand pharmacology

BACKGROUND AND PURPOSE: The δ‐subunit‐containing GABA(A) receptors, α(4)β(1)δ and α(4)β(3)δ, in dentate gyrus granule cells (DGGCs) are known to exhibit both spontaneous channel openings (i.e. constitutive activity) and agonist‐induced current. The functional implications of spontaneous gating are u...

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Udgivet i:Br J Pharmacol
Main Authors: Dalby, Nils Ole, Falk‐Petersen, Christina Birkedahl, Leurs, Ulrike, Scholze, Petra, Krall, Jacob, Frølund, Bente, Wellendorph, Petrine
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429488/
https://ncbi.nlm.nih.gov/pubmed/32484592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15146
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