GWAS Significance Thresholds for Deep Phenotyping Studies Can Depend Upon Minor Allele Frequencies and Sample Size

An important issue affecting Genome-Wide Association Studies (GWAS) with deep phenotyping (multiple correlated phenotypes) is determining the suitable family-wise significance threshold. Straightforward family-wise correction (Bonferroni) of p <0.05 for 4.3 million genotypes and 335 phenotypes wo...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Asif, Huma, Alliey-Rodriguez, Ney, Keedy, Sarah, Tamminga, Carol A., Sweeney, John A, Pearlson, Godfrey, Clementz, Brett A., Keshavan, Matcheri S., Buckley, Peter, Liu, Chunyu, Neale, Benjamin, Gershon, Elliot S.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429341/
https://ncbi.nlm.nih.gov/pubmed/32066829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0670-3
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