DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models

Pancreatic cancer is usually advanced and drug resistant at diagnosis. A potential therapeutic approach outlined here uses nanoparticle (NP)-based drug carriers, which have unique properties that enhance intra-tumor drug exposure and reduce systemic toxicity of encapsulated drugs. Here we report tha...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Johnston, MC, Nicoll, JA, Redmond, KM, Smyth, P, Greene, MK, McDaid, WJ, Chan, DKW, Crawford, N, Stott, KJ, Fox, JP, Straubinger, NL, Roche, S, Clynes, M, Straubinger, RM, Longley, DB, Scott, CJ
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429293/
https://ncbi.nlm.nih.gov/pubmed/32504778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.05.046
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