Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of...

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Pubblicato in:Sci Adv
Autori principali: Do-Umehara, Hanh Chi, Chen, Cong, Zhang, Qiao, Misharin, Alexander V., Abdala-Valencia, Hiam, Casalino-Matsuda, S. Marina, Reyfman, Paul A., Anekalla, Kishore R., Gonzalez-Gonzalez, Francisco J., Sala, Marc A., Peng, Chao, Wu, Ping, Wong, Catherine C. L., Kalhan, Ravi, Bharat, Ankit, Perlman, Harris, Ridge, Karen M., Sznajder, Jacob I., Sporn, Peter H. S., Chandel, Navdeep S., Yu, Jindan, Fu, Xiangdong, Petrache, Irina, Tuder, Rubin, Budinger, G. R. Scott, Liu, Jing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428331/
https://ncbi.nlm.nih.gov/pubmed/32851183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb7238
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