Mechanism of ribosome rescue by alternative ribosome-rescue factor B

Alternative ribosome-rescue factor B (ArfB) rescues ribosomes stalled on non-stop mRNAs by releasing the nascent polypeptide from the peptidyl-tRNA. By rapid kinetics we show that ArfB selects ribosomes stalled on short truncated mRNAs, rather than on longer mRNAs mimicking pausing on rare codon clu...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Chan, Kai-Hsin, Petrychenko, Valentyn, Mueller, Claudia, Maracci, Cristina, Holtkamp, Wolf, Wilson, Daniel N., Fischer, Niels, Rodnina, Marina V.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427801/
https://ncbi.nlm.nih.gov/pubmed/32796827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17853-7
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