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Knockdown of lincRNA PADNA promotes bupivacaine-induced neurotoxicity by miR-194/FBXW7 axis

BACKGROUND: The aim of the study was to explore the function and mechanism of lincRNA PADNA in bupivacaine-induced neurotoxicity. METHODS: Mouse DRG neurons were cultured in vitro and treated with bupivacaine to establish a neurotoxicity model. Caspase3 activity, cell viability, and TUNEL assays wer...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Yuning, Fan, Liang, Chen, Tenghuan, Wang, Zhenhua, Nan, Shengkai, Gong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427065/
https://ncbi.nlm.nih.gov/pubmed/32791990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00209-8
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