Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ɛ4

PURPOSE: Prior studies have demonstrated that microglial activation is involved in the pathogenesis of primary open-angle glaucoma (POAG). Here we sought to identify genetic associations between POAG and variants in APOE and TREM2, genes associated with Alzheimer disease (AD) that critically regulat...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Margeta, Milica A., Letcher, Sophia M., Igo, Robert P., Cooke Bailey, Jessica N., Pasquale, Louis R., Haines, Jonathan L., Butovsky, Oleg, Wiggs, Janey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2020
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425753/
https://ncbi.nlm.nih.gov/pubmed/32614373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.8.3
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