Excess Transforming Growth Factor-α Changed the Cell Properties of Corneal Epithelium and Stroma

PURPOSE: This study is to investigate the corneal anomaly caused by excess transforming growth factor-α (TGF-α) during mouse development. METHODS: Bitransgenic Kera(RT)/TGF-α mice, generated via cross-mating tetO-TGF-α and Kera(RT) mice, were induced to overexpress TGF-α by doxycycline commencing at...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Zhang, Lingling, Yuan, Yong, Yeh, Lung-Kun, Dong, Fei, Zhang, Jianhua, Okada, Yuka, Kao, Winston W Y., Liu, Chia-Yang, Zhang, Yujin
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Cornea
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425719/
https://ncbi.nlm.nih.gov/pubmed/32668000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.8.20
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