XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy

PURPOSE: Leber hereditary optic neuropathy (LHON) is a genetic form of vision loss that occurs primarily owing to mutations in the nicotinamide adenine dinucleotide dehydrogenase (ND) subunits that make up complex I of the electron transport chain. LHON mutations result in the apoptotic death of ret...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Wassmer, Sarah J., De Repentigny, Yves, Sheppard, Derek, Lagali, Pamela S., Fang, Lijun, Coupland, Stuart G., Kothary, Rashmi, Guy, John, Hauswirth, William W., Tsilfidis, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425697/
https://ncbi.nlm.nih.gov/pubmed/32735323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.8.49
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