Bortezomib at therapeutic doses poorly passes the blood–brain barrier and does not impair cognition

The 26S proteasome inhibitor bortezomib is currently used to treat multiple myeloma but also is effective in the treatment of antibody-mediated autoimmune disorders. One clinical concern is bortezomib’s toxicity towards the (central) nervous system. We used standardized neuropsychological testing to...

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Foilsithe in:Brain Commun
Main Authors: Huehnchen, Petra, Springer, Andreas, Kern, Johannes, Kopp, Ute, Kohler, Siegfried, Alexander, Tobias, Hiepe, Falk, Meisel, Andreas, Boehmerle, Wolfgang, Endres, Matthias
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425526/
https://ncbi.nlm.nih.gov/pubmed/32954282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa021
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