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Dependence, withdrawal and rebound of CNS drugs: an update and regulatory considerations for new drugs development

The purpose of this article is to describe dependence and withdrawal phenomena related to CNS drugs discontinuation and to clarify issues related to the evaluation of clinical drug withdrawal and rebound as they relate to safety in new drug development. The article presents current understanding and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Brain Commun
Main Authors: Lerner, Alicja, Klein, Michael
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425303/
https://ncbi.nlm.nih.gov/pubmed/32954266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcz025
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