Modeling and analysis of Hi-C data by HiSIF identifies characteristic promoter-distal loops

Current computational methods on Hi-C analysis focused on identifying Mb-size domains often failed to unveil the underlying functional and mechanistic relationship of chromatin structure and gene regulation. We developed a novel computational method HiSIF to identify genome-wide interacting loci. We...

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Publicat a:Genome Med
Autors principals: Zhou, Yufan, Cheng, Xiaolong, Yang, Yini, Li, Tian, Li, Jingwei, Huang, Tim H.-M., Wang, Junbai, Lin, Shili, Jin, Victor X.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425017/
https://ncbi.nlm.nih.gov/pubmed/32787954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00769-8
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