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PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity
Alzheimer’s disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in Aβ(42) production and turnover, but whether it plays a direct role in modulating Aβ(42) toxicity...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7424762/ https://ncbi.nlm.nih.gov/pubmed/32592479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa125 |
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