Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model

BACKGROUND: Cyclosporine A (CsA) is an essential immunosuppressant in organ transplantation. However, its chronic nephrotoxicity is an obstacle to long allograft survival that has not been overcome. Nuclear factor-κB (NF-κB) is activated in the renal tissue in CsA nephropathy. In this study, we aime...

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Udgivet i:BMC Pharmacol Toxicol
Main Authors: Morita, Shinya, Shinoda, Kazunobu, Yoshida, Tadashi, Shimoda, Masayuki, Kanno, Yoshihiko, Mizuno, Ryuichi, Kono, Hidaka, Asanuma, Hiroshi, Nakagawa, Ken, Umezawa, Kazuo, Oya, Mototsugu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424678/
https://ncbi.nlm.nih.gov/pubmed/32787951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-020-00432-3
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