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ROS Regulate Caspase-Dependent Cell Delamination without Apoptosis in the Drosophila Pupal Notum

Thorax fusion occurs in the midline of the Drosophila pupal notum and involves epithelial cell delamination requiring apoptotic signaling. By genetic screening, we found that NADPH oxidases (Nox and Duox) associated with superoxide anion (O˙(-)(2)) are responsible for caspase-3 activation and delami...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Fujisawa, Yuya, Shinoda, Natsuki, Chihara, Takahiro, Miura, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424206/
https://ncbi.nlm.nih.gov/pubmed/32791328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101413
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