Dapagliflozin Promotes Neovascularization by Improving Paracrine Function of Skeletal Muscle Cells in Diabetic Hindlimb Ischemia Mice Through PHD2/HIF-1α Axis

Diabetes mellitus is associated with a high risk of hindlimb ischemia (HLI) progression and an inevitably poor prognosis, including worse limb salvage and mortality. Skeletal muscle cells can secrete angiogenic factors, which could promote neovascularization and blood perfusion recovery. Thus, parac...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Nugrahaningrum, Dyah Ari, Marcelina, Olivia, Liu, Caiping, Wu, Shourong, Kasim, Vivi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424065/
https://ncbi.nlm.nih.gov/pubmed/32848736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01104
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