Dapagliflozin Promotes Neovascularization by Improving Paracrine Function of Skeletal Muscle Cells in Diabetic Hindlimb Ischemia Mice Through PHD2/HIF-1α Axis

Diabetes mellitus is associated with a high risk of hindlimb ischemia (HLI) progression and an inevitably poor prognosis, including worse limb salvage and mortality. Skeletal muscle cells can secrete angiogenic factors, which could promote neovascularization and blood perfusion recovery. Thus, parac...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Nugrahaningrum, Dyah Ari, Marcelina, Olivia, Liu, Caiping, Wu, Shourong, Kasim, Vivi
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424065/
https://ncbi.nlm.nih.gov/pubmed/32848736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01104
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