The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation

BACKGROUND. Potential adverse effects, such as functional impairment of islets, render conventional immunosuppressive drugs unsuitable for use in islet transplantation. In addition, as a single therapy, they cannot prolong islet allograft survival. Here, we investigated the utility of the mitogen-ac...

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Vydáno v:Transplant Direct
Hlavní autoři: Tada, Seiichiro, Anazawa, Takayuki, Shindo, Takero, Yamane, Kei, Inoguchi, Kenta, Fujimoto, Nanae, Nagai, Kazuyuki, Masui, Toshihiko, Okajima, Hideaki, Takaori, Kyoichi, Sumi, Shoichiro, Uemoto, Shinji
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2020
Témata:
Pancreas and Islet Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423917/
https://ncbi.nlm.nih.gov/pubmed/32851124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TXD.0000000000001045
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