Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis

In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shiau, Dong-Jer, Kuo, Wan-Ting, Davuluri, Goutham Venkata Naga, Shieh, Chi-Chang, Tsai, Pei-Jane, Chen, Chien-Chin, Lin, Yee-Shin, Wu, Yi-Zhen, Hsiao, Yu-Peng, Chang, Chih-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423894/
https://ncbi.nlm.nih.gov/pubmed/32788720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70137-4
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