Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits

Switches between global sleep and wakefulness states are believed to be dictated by top-down influences arising from subcortical nuclei. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterized by a substantially reduced propensity to transition...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Banks, Gareth T., Guillaumin, Mathilde C. C., Heise, Ines, Lau, Petrina, Yin, Minghui, Bourbia, Nora, Aguilar, Carlos, Bowl, Michael R., Esapa, Chris, Brown, Laurence A., Hasan, Sibah, Tagliatti, Erica, Nicholson, Elizabeth, Bains, Rasneer Sonia, Wells, Sara, Vyazovskiy, Vladyslav V., Volynski, Kirill, Peirson, Stuart N., Nolan, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423362/
https://ncbi.nlm.nih.gov/pubmed/32851175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb3567
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