Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia

Proper lung development depends on the precise temporal and spatial expression of several morphogenic factors, including Fgf10, Fgf9, Shh, Bmp4, and Tgf-β. Over- or under-expression of these molecules often leads to aberrant embryonic or postnatal lung development. Herein, we deleted the Tgf-β1 gene...

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Bibliographic Details
Published in:Lab Invest
Main Authors: Noe, Niki, Shim, Ashley, Millette, Katelyn, Luo, Yongfeng, Azhar, Mohamad, Shi, Wei, Warburton, David, Turcatel, Gianluca
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422700/
https://ncbi.nlm.nih.gov/pubmed/31028279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-019-0256-3
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