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In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs
Antimalarial candidates possessing novel mechanisms of action are needed to control drug resistant Plasmodium falciparum. We were drawn to Malaria Box compound 1 (MMV665831) by virtue of its excellent in vitro potency, and twelve analogs were prepared to probe its structure-activity relationship. Mo...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7422479/ https://ncbi.nlm.nih.gov/pubmed/32738996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127348 |
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