RAS/CBL mutations predict resistance to JAK inhibitors in myelofibrosis and are associated with poor prognostic features

The dysregulation of the JAK/STAT pathway drives the pathogenesis of myelofibrosis (MF). Recently, several JAK inhibitors (JAKis) have been developed for treating MF. Select mutations (MTs) have been associated with impaired outcomes and are currently incorporated in molecularly annotated prognostic...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Coltro, Giacomo, Rotunno, Giada, Mannelli, Lara, Mannarelli, Carmela, Fiaccabrino, Sara, Romagnoli, Simone, Bartalucci, Niccolò, Ravenda, Enrica, Gelli, Eleonora, Sant’Antonio, Emanuela, Patnaik, Mrinal M., Tefferi, Ayalew, Vannucchi, Alessandro M., Guglielmelli, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422130/
https://ncbi.nlm.nih.gov/pubmed/32777067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002175
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