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Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis

Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases (ADHs) or retinol dehydrogenases (RDHs); and oxidation of retinaldehyd...

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Vydáno v:Development
Hlavní autoři: Ono, Kazuya, Sandell, Lisa L., Trainor, Paul A., Wu, Doris K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7420839/
https://ncbi.nlm.nih.gov/pubmed/32665247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.192070
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