Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by both the normal microbiota and enteric pathogens. Some members of the microbiota utilise mucin glycoproteins as a nutrient source, but a detailed understanding of the mechanisms used to breakdown these...

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Udgivet i:Nat Commun
Main Authors: Crouch, Lucy I., Liberato, Marcelo V., Urbanowicz, Paulina A., Baslé, Arnaud, Lamb, Christopher A., Stewart, Christopher J., Cooke, Katie, Doona, Mary, Needham, Stephanie, Brady, Richard R., Berrington, Janet E., Madunic, Katarina, Wuhrer, Manfred, Chater, Peter, Pearson, Jeffery P., Glowacki, Robert, Martens, Eric C., Zhang, Fuming, Linhardt, Robert J., Spencer, Daniel I. R., Bolam, David N.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419316/
https://ncbi.nlm.nih.gov/pubmed/32782292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17847-5
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