Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regulate inflammatory gene transcription. We show that...

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Detalhes bibliográficos
Publicado no:Cardiovasc Ther
Main Authors: Wasiak, Sylwia, Gilham, Dean, Daze, Emily, Tsujikawa, Laura M., Halliday, Christopher, Stotz, Stephanie C., Rakai, Brooke D., Fu, Li, Jahagirdar, Ravi, Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Kulikowski, Ewelina
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416228/
https://ncbi.nlm.nih.gov/pubmed/32821285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/9397109
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