Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality

Background: Circular RNAs (circRNAs) are a new class of RNAs with medical significance. Compared to that of linear mRNA transcripts, the stability of circRNAs against degradation owing to their circular structure is considered advantageous for their use as biomarkers. As systematic studies on the st...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Rochow, Hannah, Franz, Antonia, Jung, Monika, Weickmann, Sabine, Ralla, Bernhard, Kilic, Ergin, Stephan, Carsten, Fendler, Annika, Jung, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415809/
https://ncbi.nlm.nih.gov/pubmed/32802191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.46341
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