Therapeutic efficacy of immune stimulatory thymidine kinase and fms-like tyrosine kinase 3 ligand (TK/Flt3L) gene therapy in a mouse model of high grade brainstem glioma

PURPOSE: Diffuse intrinsic pontine glioma (DIPG) bears a dismal prognosis. A genetically engineered brainstem glioma model harboring the recurrent DIPG mutation, ACVR1-G328V (mACVR1), was developed for testing an immune-stimulatory gene therapy. EXPERIMENTAL DESIGN: We utilized the Sleeping Beauty t...

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Publié dans:Clin Cancer Res
Auteurs principaux: Mendez, Flor M., Kadiyala, Padma, Nunez, Felipe J., Carney, Stephen, Nunez, Fernando, Gauss, Jessica C., Ravindran, Ramya, Pawar, Sheeba, Edwards, Marta, Garcia-Fabiani, Maria B., Haase, Santiago, Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415674/
https://ncbi.nlm.nih.gov/pubmed/32332014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3714
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