Using whole-genome sequencing data to derive the homologous recombination deficiency scores

The homologous recombination deficiency (HRD) score was developed using whole-genome copy number data derived from arrays as a way to infer deficiency in the homologous recombination DNA damage repair pathway (in particular BRCA1 or BRCA2 deficiency) in breast cancer samples. The score has utility i...

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Vydáno v:NPJ Breast Cancer
Hlavní autoři: de Luca, Xavier M., Newell, Felicity, Kazakoff, Stephen H., Hartel, Gunter, McCart Reed, Amy E., Holmes, Oliver, Xu, Qinying, Wood, Scott, Leonard, Conrad, Pearson, John V., Lakhani, Sunil R., Waddell, Nicola, Nones, Katia, Simpson, Peter T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414867/
https://ncbi.nlm.nih.gov/pubmed/32818150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-020-0172-0
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