Using whole-genome sequencing data to derive the homologous recombination deficiency scores

The homologous recombination deficiency (HRD) score was developed using whole-genome copy number data derived from arrays as a way to infer deficiency in the homologous recombination DNA damage repair pathway (in particular BRCA1 or BRCA2 deficiency) in breast cancer samples. The score has utility i...

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Bibliografiske detaljer
Udgivet i:NPJ Breast Cancer
Main Authors: de Luca, Xavier M., Newell, Felicity, Kazakoff, Stephen H., Hartel, Gunter, McCart Reed, Amy E., Holmes, Oliver, Xu, Qinying, Wood, Scott, Leonard, Conrad, Pearson, John V., Lakhani, Sunil R., Waddell, Nicola, Nones, Katia, Simpson, Peter T.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414867/
https://ncbi.nlm.nih.gov/pubmed/32818150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-020-0172-0
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