Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans

Efficacy evaluation through human trials is crucial for advancing a vaccine candidate to clinics. Next-generation sequencing (NGS) can be used to quantify B cell repertoire response and trace antibody lineages during vaccination. Here, we demonstrate this application with a case study of Hecolin®, t...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Wen, Gui-Ping, He, Linling, Tang, Zi-Min, Wang, Si-Ling, Zhang, Xu, Chen, Yuan-Zhi, Lin, Xiaohe, Liu, Chang, Chen, Jia-Xin, Ying, Dong, Chen, Zi-Hao, Wang, Ying-Bin, Luo, Wen-Xin, Huang, Shou-Jie, Li, Shao-Wei, Zhang, Jun, Zheng, Zi-Zheng, Zhu, Jiang, Xia, Ning-Shao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414844/
https://ncbi.nlm.nih.gov/pubmed/32769993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17737-w
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