Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication

For positive-strand RNA [(+)RNA] viruses, the major target for antiviral therapies is genomic RNA replication, which occurs at poorly understood membrane-bound viral RNA replication complexes. Recent cryoelectron microscopy (cryo-EM) of nodavirus RNA replication complexes revealed that the viral dou...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Unchwaniwala, Nuruddin, Zhan, Hong, Pennington, Janice, Horswill, Mark, den Boon, Johan A., Ahlquist, Paul
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414174/
https://ncbi.nlm.nih.gov/pubmed/32690711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006165117
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items