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Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo

The present study involves the development of Dipivefrin hydrochloride (DV) containing Poloxamers (P407 and P188)-Carbopol-934 (CP) based thermoresponsive-gels for the management of elevated intraocular pressure (IOP). Optimal formulation was evaluated for gelation temperature (T(gel)), physicochemi...

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Detalhes bibliográficos
Publicado no:Saudi Pharm J
Main Authors: Alkholief, Musaed, Kalam, Mohd Abul, Almomen, Aliyah, Alshememry, Abdullah, Alshamsan, Aws
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414100/
https://ncbi.nlm.nih.gov/pubmed/32792847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2020.07.001
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