Morphological profiling of tubercle bacilli identifies drug pathways of action

Morphological profiling is a method to classify target pathways of antibacterials based on how bacteria respond to treatment through changes to cellular shape and spatial organization. Here we utilized the cell-to-cell variation in morphological features of Mycobacterium tuberculosis bacilli to deve...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Smith, Trever C., Pullen, Krista M., Olson, Michaela C., McNellis, Morgan E., Richardson, Ian, Hu, Sophia, Larkins-Ford, Jonah, Wang, Xin, Freundlich, Joel S., Ando, D. Michael, Aldridge, Bree B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414088/
https://ncbi.nlm.nih.gov/pubmed/32680963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002738117
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