Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Several studies show that the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of the immune cell composition of two severe-stage...

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Pubblicato in:Nat Commun
Autori principali: Guo, Chuang, Li, Bin, Ma, Huan, Wang, Xiaofang, Cai, Pengfei, Yu, Qiaoni, Zhu, Lin, Jin, Liying, Jiang, Chen, Fang, Jingwen, Liu, Qian, Zong, Dandan, Zhang, Wen, Lu, Yichen, Li, Kun, Gao, Xuyuan, Fu, Binqing, Liu, Lianxin, Ma, Xiaoling, Weng, Jianping, Wei, Haiming, Jin, Tengchuan, Lin, Jun, Qu, Kun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413381/
https://ncbi.nlm.nih.gov/pubmed/32764665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17834-w
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