Membrane Cholesterol Is Crucial for Clostridium difficile Surface Layer Protein Binding and Triggering Inflammasome Activation

Clostridium difficile, an obligate anaerobic gram-positive bacillus, generates spores and is commonly found colonizing the human gut. Patients with C. difficile infection (CDI) often exhibit clinical manifestations of pseudomembranous colitis or antibiotic-associated diarrhea. Surface layer proteins...

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Vydáno v:Front Immunol
Hlavní autoři: Chen, Yu, Huang, Kai, Chen, Liang-Kuei, Wu, Hui-Yu, Hsu, Chih-Yu, Tsai, Yau-Sheng, Ko, Wen-Chien, Tsai, Pei-Jane
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411348/
https://ncbi.nlm.nih.gov/pubmed/32849582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01675
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