Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary nonperfusion and endothelial cell (EC) loss. We investigated the role of EC apoptosis in this process using a mouse mode...

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Pubblicato in:J Clin Invest
Autori principali: Grant, Zoe L., Whitehead, Lachlan, Wong, Vickie H.Y., He, Zheng, Yan, Richard Y., Miles, Abigail R., Benest, Andrew V., Bates, David O., Prahst, Claudia, Bentley, Katie, Bui, Bang V., Symons, Robert C.A., Coultas, Leigh
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410052/
https://ncbi.nlm.nih.gov/pubmed/32427589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127668
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