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Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary nonperfusion and endothelial cell (EC) loss. We investigated the role of EC apoptosis in this process using a mouse mode...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Grant, Zoe L., Whitehead, Lachlan, Wong, Vickie H.Y., He, Zheng, Yan, Richard Y., Miles, Abigail R., Benest, Andrew V., Bates, David O., Prahst, Claudia, Bentley, Katie, Bui, Bang V., Symons, Robert C.A., Coultas, Leigh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410052/
https://ncbi.nlm.nih.gov/pubmed/32427589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127668
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