Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

Haploinsufficiency of factors governing genome stability underlies hereditary breast and ovarian cancer. One significant pathway that is disabled as a result is homologous recombination repair (HRR). With the aim of identifying new candidate genes, we examined early-onset breast cancer patients nega...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zarrizi, Reihaneh, Higgs, Martin R., Voßgröne, Karolin, Rossing, Maria, Bertelsen, Birgitte, Bose, Muthiah, Kousholt, Arne Nedergaard, Rösner, Heike, Network, the COMPLEXO, Ejlertsen, Bent, Stewart, Grant S., Nielsen, Finn Cilius, Sørensen, Claus S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410048/
https://ncbi.nlm.nih.gov/pubmed/32379725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127521
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