Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic “megamitochondria” with altered MAMs in brown adipocytes lacking the Se...

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Udgivet i:Science
Main Authors: Zhou, Zhangsen, Torres, Mauricio, Sha, Haibo, Halbrook, Christopher J., den Bergh, Françoise Van, Reinert, Rachel B., Yamada, Tatsuya, Wang, Siwen, Luo, Yingying, Hunter, Allen H., Wang, Chunqing, Sanderson, Thomas H., Liu, Meilian, Taylor, Aaron, Sesaki, Hiromi, Lyssiotis, Costas A., Wu, Jun, Kersten, Sander, Beard, Daniel A., Qi, Ling
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409365/
https://ncbi.nlm.nih.gov/pubmed/32193362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay2494
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