Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC) staining remain without any identifiable germline mutation of DNA mismatch repair (MMR) genes. MMR proteins form heterodimeric complexes, giving rise to distinct IHC patterns when mutant. Potential reasons for not finding a...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Olkinuora, Alisa, Gylling, Annette, Almusa, Henrikki, Eldfors, Samuli, Lepistö, Anna, Mecklin, Jukka-Pekka, Nieminen, Taina Tuulikki, Peltomäki, Päivi
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408769/
https://ncbi.nlm.nih.gov/pubmed/32660107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071853
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