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Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status
Poly (ADP-ribose) polymerase (PARP) inhibition in BRCA-mutated cells results in an incapacity to repair DNA damage, leading to cell death caused by synthetic lethality. Within the treatment options for advanced triple negative breast cancer, the PARP inhibitor olaparib is only given to patients with...
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| 發表在: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7408583/ https://ncbi.nlm.nih.gov/pubmed/32630796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071769 |
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