Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters

Developmental changes in the biological processes involved in the disposition of drugs, such as membrane transporter expression and activity, may alter the drug exposure and clearance in pediatric patients. Physiologically based pharmacokinetic (PBPK) models take these age-dependent changes into acc...

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Publicado en:J Clin Pharmacol
Main Authors: Cheung, Kit Wun Kathy, van Groen, Bianca D., Burckart, Gilbert J., Zhang, Lei, de Wildt, Saskia N., Huang, Shiew-Mei
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408403/
https://ncbi.nlm.nih.gov/pubmed/31502692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1489
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