MRIP Regulates the Myosin IIA Activity and DDR1 Function to Enable Collagen Tractional Remodeling

DDR1 is a collagen adhesion-mechanoreceptor expressed in fibrotic lesions. DDR1 mediates non-muscle myosin IIA (NMIIA)-dependent collagen remodeling. We discovered that the myosin phosphatase Rho-interacting protein (MRIP), is enriched in DDR1-NMIIA adhesions on collagen. MRIP regulates RhoA- and my...

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Published in:Cells
Main Authors: Coelho, Nuno M., Wang, Andrew, Petrovic, Petar, Wang, Yongqiang, Lee, Wilson, McCulloch, Christopher A.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407560/
https://ncbi.nlm.nih.gov/pubmed/32664526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071672
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