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MRIP Regulates the Myosin IIA Activity and DDR1 Function to Enable Collagen Tractional Remodeling
DDR1 is a collagen adhesion-mechanoreceptor expressed in fibrotic lesions. DDR1 mediates non-muscle myosin IIA (NMIIA)-dependent collagen remodeling. We discovered that the myosin phosphatase Rho-interacting protein (MRIP), is enriched in DDR1-NMIIA adhesions on collagen. MRIP regulates RhoA- and my...
में बचाया:
| में प्रकाशित: | Cells |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
MDPI
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7407560/ https://ncbi.nlm.nih.gov/pubmed/32664526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071672 |
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